Setting the Mood: An Examination of the Roles of Romance-Related Mood, Situational Similarity, and Character Attribute Similarity in Selective Exposure to Romantic Comedies

Two studies were conducted in order to explore how romance-related mood, situational similarity, and character attribute similarity affect selective exposure to romantic comedies. Eight hypotheses were proposed based on traditional mood management theory (MMT). MMT predicts that people make media selection choices based on a desire to alter a negative mood state and achieve a positive mood state (Zillmann, 1988; Zillmann & Bryant, 1985). For this study in particular, MMT predicts that people in a negative romance-related mood would choose to avoid media content that reminds them of their negative romance-related mood. Content could remind participants of their negative romance-related mood through either situational similarity (Study 1) or character attribute similarity (Study 2). Situational similarity was operationalized through subgenre (female-led comedies vs. traditional romantic comedies), and character attribute similarity was operationalized through age. Experimental research was conducted with college-aged female participants in order to test the hypotheses. Results from a series of ANOVAs and hierarchical regressions revealed that, in general, the hypotheses proposed in this study were not supported. In fact, this study found results contrary to predictions made based on traditional MMT predicted outcomes. This suggests the need for future studies of MMT and its extensions, particularly in regard to motivations for counter-hedonic media selection choices

Monitoring, Creeping, or Surveillance? A Synthesis of Online Social Information Seeking Concepts

Affordances of Internet sites and Internet-based applications make personal information about romantic partners, friends, family members, and strangers easy to obtain. People use various techniques to find information about others, capitalizing on online affordances by using search engines to find relevant websites and databases; scouring the target’s social media or social networking site presence; accessing information about the target via their links or network association with others on social media; or asking questions or crowdsourcing information through online channels. Researchers have coined an assortment of terms to describe online social information seeking behaviors, such as interpersonal electronic surveillance, social surveillance, monitoring, patient-targeted Googling, cybervetting, websleuthing, human flesh search, lateral surveillance, Facebook surveillance, and Facebook stalking. Although considerable research has examined these behaviors, there has been little effort to clarify the concepts themselves. As a result, the literature is currently full of inconsistent and overlapping conceptualizations. To synthesize these concepts for future research, this review examines 73 online social information seeking concepts extracted from 186 articles. Specifically, the concepts are reviewed in light of their scope; the information seeker or target of information seeking (e.g., romantic partners, parents, children, employees, criminals); motives for information seeking (e.g., uncertainty, threat, curiosity); and the intensity of the behavior. Recommendations are provided for future research, such as employing clear conceptualizations and incorporating affordances. Finally, we offer a decision tree that researchers can use to help select appropriate terms to use in their work moving forward

Investigation of hospital discharge cases and SARS-CoV-2 introduction into Lothian care homes

Background The first epidemic wave of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in Scotland resulted in high case numbers and mortality in care homes. In Lothian, over one-third of care homes reported an outbreak, while there was limited testing of hospital patients discharged to care homes. Aim To investigate patients discharged from hospitals as a source of SARS-CoV-2 introduction into care homes during the first epidemic wave. Methods A clinical review was performed for all patients discharges from hospitals to care homes from 1st March 2020 to 31st May 2020. Episodes were ruled out based on coronavirus disease 2019 (COVID-19) test history, clinical assessment at discharge, whole-genome sequencing (WGS) data and an infectious period of 14 days. Clinical samples were processed for WGS, and consensus genomes generated were used for analysis using Cluster Investigation and Virus Epidemiological Tool software. Patient timelines were obtained using electronic hospital records. Findings In total, 787 patients discharged from hospitals to care homes were identified. Of these, 776 (99%) were ruled out for subsequent introduction of SARS-CoV-2 into care homes. However, for 10 episodes, the results were inconclusive as there was low genomic diversity in consensus genomes or no sequencing data were available. Only one discharge episode had a genomic, time and location link to positive cases during hospital admission, leading to 10 positive cases in their care home. Conclusion The majority of patients discharged from hospitals were ruled out for introduction of SARS-CoV-2 into care homes, highlighting the importance of screening all new admissions when faced with a novel emerging virus and no available vaccine

SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

Vaccines based on the spike protein of SARS-CoV-2 are a cornerstone of the public health response to COVID-19. The emergence of hypermutated, increasingly transmissible variants of concern (VOCs) threaten this strategy. Omicron (B.1.1.529), the fifth VOC to be described, harbours multiple amino acid mutations in spike, half of which lie within the receptor-binding domain. Here we demonstrate substantial evasion of neutralization by Omicron BA.1 and BA.2 variants in vitro using sera from individuals vaccinated with ChAdOx1, BNT162b2 and mRNA-1273. These data were mirrored by a substantial reduction in real-world vaccine effectiveness that was partially restored by booster vaccination. The Omicron variants BA.1 and BA.2 did not induce cell syncytia in vitro and favoured a TMPRSS2-independent endosomal entry pathway, these phenotypes mapping to distinct regions of the spike protein. Impaired cell fusion was determined by the receptor-binding domain, while endosomal entry mapped to the S2 domain. Such marked changes in antigenicity and replicative biology may underlie the rapid global spread and altered pathogenicity of the Omicron variant

Social Media’s Role in Romantic Partners’ Retroactive Jealousy: Social Comparison, Uncertainty, and Information Seeking

Social media often have a dark side in romantic relationships. Affordances such as persistence, association, and visibility can promote romantic jealousy and the salience of relationship threats, including ex-partners. Retroactive jealousy occurs when a person feels upset about their partner’s romantic history even though ex-partners are not actively interfering in the current relationship. Interviews ( N  = 36) probed how participants felt social networking sites (SNSs) promoted and mitigated retroactive romantic jealousy. Furthermore, we examined the consequences of these experiences. Participants indicated that SNSs lead to retroactive jealousy via social comparison, digital remnants, and relational uncertainty. In addition, participants used SNSs to gather information or monitor their partners. These information-seeking activities allowed them to disparage a romantic partner’s exes; avoid direct, interactive information seeking about exes; and digitally fact-check information the partner disclosed. Some participants reframed information about the ex-relationship or actively avoided SNSs to reduce retroactive jealousy. Although SNSs may be used in an attempt to mitigate retroactive jealousy, our findings suggest this strategy may backfire in some cases

The genomics of colorectal cancer in populations with African and European ancestry

Black people have a higher incidence of colorectal cancer and worse survival rates when compared with white people. Comprehensive genomic profiling was performed in 46,140 colorectal adenocarcinoma cases. Ancestry-informative markers identified 5,301 patients of African descent (AFR) and 33,770 patients of European descent (EUR). AFR were younger, had fewer microsatellite instability-high (MSI-H) tumors, and had significantly more frequent alterations in KRAS, APC, and PIK3CA. AFR had increased frequency of KRAS mutations, specifically KRASG12D and KRASG13. There were no differences in rates of actionable kinase driver alterations (HER2, MET, NTRK, ALK, ROS1, and RET). In patients with young-onset colorectal cancer ( Significance: KRAS (particularly KRASG12D/G13), APC, and PIK3CA were more frequently altered in AFR who had a lower frequency of MSI-H tumors. There were no differences in actionable kinase driver alterations. In young-onset colorectal cancer, both ancestries had a similar frequency of MSI-H/TMB-H tumors, but strikingly different trends in APC. See related commentary by Eng and Holowatyj, p. 1187. This article is highlighted in the In This Issue feature, p. 1171.</p